Investor Relations/Corporate Communications – Director/Senior Director

Pliant Therapeutics is a clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The company’s lead product candidate, PLN-74809, is designed to be a selective inhibitor of αvβ1 and αvβ6 integrins that play a key role in multiple fibrotic pathways. Pliant’s second product candidate, PLN-1474, is designed to be an oral, small molecule selective inhibitor of αvβ1, targeting late-stage liver fibrosis and is partnered with Novartis.   The Company is seeking passionate, creative and dedicated individuals to join our team and contribute to our mission.

Description

This is an exceptional opportunity to establish the Investor Relations and Corporate Communications function in a new public company driven by a leadership team of proven drug developers.

Reporting to the CFO, the successful candidate will be responsible for developing and managing relationships within the investment community, including investors and sell-side analysts, via collaboration with an external IR partner.   This individual will also be responsible for all corporate communications, including corporate visibility, media and public relations, alignment with corporate strategy and public affairs, via collaboration with an external PR partner.  The Director, IR and Corporate Communications will contribute to company branding, employer branding and messaging strategy and execution, collaborating with internal Functional Leads and Human Resources. This individual will work closely and collaborate with the Leadership Team.

 

Essential Functions

 

  • Develop and oversee a comprehensive investor relations strategy.
  • Identify and prioritize management attendance at investor conferences and analyst meetings.
  • Develop the short and long-term corporate messaging aligned by stakeholder and channel.
  • Responsibility for all key corporate communications functions, including concept development, writing/editing, production, and distribution; as well as management of external agencies.
  • Develop materials for reporting and special announcements, including key messages, presentations, conference call scripts, Q&As, press releases and briefing information.
  • Develop and evolve the communication strategy to align with changes to the business.
  • Assures information complies with all product promotion guidelines, SEC regulations and adheres to Regulation FD.
  • Develop and manage digital and social media campaigns for the Company.

 

 

Qualifications

To perform this job successfully, an individual must be able to perform each essential duty. The requirements listed below are representative of the knowledge, skill, and/or ability required.

  • 8-10 years in the pharmaceutical industry, with direct experience leading Investor Relations and Corporate Communications at a public biotech company.
  • Bachelor’s degree required; Master’s degree preferred in a related discipline.
  • Demonstrated experience to lead and influence within a matrixed environment.
  • Established relationships and credibility with the investment community, media and biopharma journalists.
  • Proven track record delivering clear consistent messaging of scientific and clinical concepts across multiple stakeholders / audiences.
  • Experience in managing and overseeing contract IR/PR agencies and vendors
  • Strong presentation skills.
  • Experience setting and managing budgets.
  • Must be independent and highly motivated with the ability to multi-task in a fast-paced environment.
  • Behaves in alignment with Pliant’s values.

Research Associate II, Medicinal Chemistry

Description:

Pliant Therapeutics is a clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate openings are available for a Research Associate in Chemistry.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers.  The primary responsibility of this position will be synthesis, purification, and characterization of novel biologically active molecules. The successful candidate will work with minimal supervision of a Senior Research Associate or Scientist.  The candidate will have the ability to use the chemical literature to plan and propose experiments and synthetic schemes and evaluate structure and purity of products using modern analytical techniques.

 

Responsibilities:

  • Participate in the design, synthesis, purification, and characterization of novel biologically active molecules.
  • Contribute to exploratory research and lead optimization projects, and collaborate closely with colleagues in other groups.
  • Summarize/interpret data and present findings in research meetings.
  • Independently execute assigned tasks following appropriate laboratory/technical procedures under supervision.
  • Design and implement new laboratory techniques, troubleshoot experiments, and ensure experiments are well designed and performed to a high standard.

 

Job Requirements:

  • BS/MS in Chemistry with 5-7 years of relevant experience in synthetic organic/medicinal chemistry after the BS degree.
  • Potential to learn and adapt in a fast moving environment.
  • Demonstrated expertise in organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, MS, HPLC, etc.).
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
  • Demonstrated ability to work independently and perform well in a team environment.

Medical Director/Senior Medical Director

Pliant Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrosis. Pliant seeks to develop targeted treatments to slow or halt the progression of multiple life-threatening fibrotic diseases. The company’s lead product candidate, PLN-74809, is designed to be a selective inhibitor of αvβ6 and αvβ1 integrins, which play key roles in multiple fibrotic pathways. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration in both idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC), and is currently in Phase 2 testing for IPF. Pliant’s second product candidate, PLN-1474, is designed to be an oral, small molecule selective inhibitor of αvβ1, targeting late-stage liver fibrosis and is partnered with Novartis.

Position Overview:

Reporting to the VP, Clinical Development, the Medical Director manages the day-to-day activities of clinical development of drug candidates, from early to late-stage, and across multiple therapeutic areas. The Medical Director will assume a hands-on role in the planning, implementation, conduct and oversight of clinical trials, in close partnership with the Clinical Operations group.

The candidate must have relevant and direct experience in clinical development within the pharmaceutical or biotech industry (at least 5 years preferred). Strong clinical background, high scientific interest and effective communication skills are required.  The Medical Director will be responsible for ensuring proper clinical conduct of study protocols in compliance with GCP and local/global trial regulations, oversee and provide clinical guidance to CRO medical monitors (and study investigators, as needed) and study team, lead development of study protocols, protocol amendments and clinical study reports. The Medical Monitor will work in close collaboration with Clinical Operations and Project Management  to achieve clinical development goals and deliverables.

ESSENTIAL DUTIES AND RESPONSIBILITIES

  • Develop study protocols and obtain cross-functional input to execute on clinical development strategies
  • Work in close collaboration with Clinical Operations and designated CROs to ensure quality and timely execution of the clinical programs (i.e.: study startup, conduct and database lock activities; medical monitor training and oversight; safety monitoring plans; protocol deviation lists; data and AE codingreviews; statistical analysis plans; develop/present clinical slides at Investigators Meetings)
  • Write/review/edit clinical study reports, investigator brochures and clinical aspects of regulatory submissions and clinical trial applications; supports all other regulatory activities, including protocol-related questions from health authorities
  • Ensure that the Clinical Development department is working in lockstep with Clinical Operations and Project Management and along with Regulatory Affairs, Drug Safety/Pharmacovigilance, Clinical Pharmacology and Medical Affairs, as appropriate, for effective and high-quality execution of various programs

Domestic and global travel may be required

KNOWLEDGE AND SKILL REQUIREMENTS:  

  • M.D. degree with a minimum of 5 years industry experience, in the management and execution of Phase 1-3 trials; clinical pharmacology background a plus
  • Experience in fibrosis and/or rare diseases is a definite plus
  • Sound and comprehensive knowledge of the drug development process, trial management and vendor oversight, safety reporting, MedDRA and WHODrug dictionaries, study methodology, data reviews, statistical analysis plans and local and global clinical trial regulations
  • High scientific acumen and demonstrated ability to independently evaluate, interpret and present complex scientific data
  • Sound understanding of statistics and demonstrated ability to critically evaluate complex drug development programs
  • Demonstrated ability to work collaboratively with a multi-disciplinary team of peers, consultants and vendors
  • Excellent communication skills including written, oral, and presentation skills.Evidence of publication of original scientific papers in translational and/or clinical research will be valued
  • Able to work effectively in a small dynamic organization; ability to assume multiple roles and responsibilities and meet stretch goals
  • Strong people management skills that focus on teamwork and building alliances; ability to resolve conflicts and to negotiate effectively
  • Positive approach to work and ability to motivate team members to meet timelines and project goals is required
  • Ability to develop strong relationships with study investigators and key opinion leaders within therapeutic area.

Senior Research Associate, DMPK

Position Overview

Pliant Therapeutics is seeking an enthusiastic Senior Research Associate to join our
department of Drug Metabolism and Pharmacokinetics (DMPK). In this rewarding, dynamic environment the successful candidate will be responsible for conducting in vitro assays including plasma protein binding, hepatocyte stability, CYP inhibition and related experiments to characterize the ADME properties of novel chemical entities. In addition, significant opportunity exists to directly support discovery project teams and represent DMPK in a highly impactful and visible role.

Responsibilities

  • Design and conduct in vitro ADME assays to support discovery/development project teams
  • Collect, analyze, summarize, and upload to internal databases and report high quality data in a timely manner
  • Effectively communicate and collaborate with multiple team members across disciplines
  • Participate in project and DMPK meetings

Experience

  • Hands-on laboratory experience with in vitro DMPK assays (plasma protein binding, metabolic stability, hepatocyte incubations, and related assays)
  • Experience with small molecule LC-MS/MS bioanalysis; sample processing and preparation
  • Solid understanding of key ADME/PK concepts and principles
  • Ability to troubleshoot in vitro assays and small molecule bioanalysis
  • Excellent interpersonal skills and team spirit
  • DMPK representation in project team environment

Education

  • Bachelor’s degree (B.S./B.A.) or equivalent in a scientifically related discipline

Senior Clinical Trial Manager

Department: Clinical Operations

Description: Pliant Therapeutics is a clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.

Position Overview: The Clinical Trial Manager is responsible for managing the day-to-day operations of assigned clinical studies to ensure completion per established project team goals and objectives.  The CTM will report to the VP, Clinical Operations and will work closely with a cross-functional team in a fast-paced high growth environment team to ensure that clinical trials are conducted on time and budget, and in accordance with applicable GCP/ICH guidelines and other regulatory requirements.

Primary Responsibilities:

  • Lead internal cross-functional study team for assigned studies to identify risks and mitigation strategies.
  • Manage the day-to-day operations of assigned studies.
  • Manage clinical research organizations (CROs) to ensure timely and quality deliverables.
  • Lead preparation of vendor requirements and project scope and selection of study vendors.
  • Lead feasibility assessment and selection of countries and sites for study conduct.
  • Implement appropriate systems, standards and processes to ensure quality at the level  of investigative sites, vendors and data.
  • Oversee maintenance of clinical trial master files.
  • Oversee the clinical aspects of timely data cleaning, data analysis and the availability of top line results; participate in data reviews.
  • Author, audit and/or edit written summaries of data reports, presentations, training  material, and study documents (including pharmacy, laboratory, and operations manuals).
  • Ensure set-up and implementation of effective investigator and site monitor training; coordinate operational and therapeutic area training for internal and external study team members.
  • Create and conduct study-specific training at investigator meetings.
  • Review study invoices and participate in accrual reviews to track the financial status of the study against budget.
  • All work must adhere to ICH Good Clinical Practice (GCP) guidelines and comply with company SOPs.

Requirements:

  • Bachelor’s degree required.
  • 10 years of experience working with CROs to manage clinical trials in US and ex-US.
  • Excellent organizational skills and attention to detail.
  • Effective communication and interpersonal skills.
  • Able to set priorities and juggle multiple demands.
  • Able to think critically and be a proactive problem-solver.
  • Able to work independently while exercising initiative, flexibility and sound judgment.
  • Comfortable working with different levels of the company including senior level management.
  • Demonstrated proficiency in Microsoft Word, PowerPoint and Excel.
  • Ability to operate in alignment with Pliant’s values

Sr. Scientist, DMPK

Sr. Scientist, DMPK

Description: 

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for meeting unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview:

Pliant is seeking a versatile, self-motivated person to become an integral part of the DMPK team.  This position will be the drug metabolism and pharmacokinetics (DMPK) lead on project teams developing small molecule modulators of clinically meaningful targets in fibrosis.

This role will interact and collaborate cross-functionally with scientists in other groups, including chemists, biologists, biochemists, structural biologists, and computational chemists.

Job Responsibilities:

  • Serve as DMPK subject matter expert on dynamic cross-functional teams, provide in vitro and in vivo drug disposition data, interpretation, and presentations to teams.
  • Work closely with internal and external resources to assure a high level of quality and timely delivery of DMPK support.
  • Design and perform PK and PK/PD analyses to answer translational questions and to provide guidance for project teams.
  • Supervise associate scientists as required.

Qualifications/Experience: 

  • Requires a highly motivated individual with PhD degree in life sciences with 3-7 year experience.
  • Demonstrates excellent scientific skills in the design, execution and analysis of DMPK studies as well as organized data management and planning skills
  • Good verbal and written communication skills, demonstrated ability to work effectively in cross-functional teams
  • Requires hands-on experience in pharmacokinetics, drug metabolism or transporters

Expertise and experience in one or more of the following areas:

  • Mechanistic PK and pharmacodynamics (PD) analysis, design, interpretation, simulation, and reporting to provide guidance for drug discovery and development projects
  • Metabolite and metabolic soft-spot identification to facilitate structure-based discovery
  • Bioanalysis with previous experience in applying automation for higher throughput

 

Scientist/Sr. Scientist Biology – Antibody Engineering

Scientist/Sr. Scientist Biology – Antibody Engineering

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview:

Immediate openings are available for Scientists/Sr. Scientists with experience in the fibrosis/inflammation area. Experience in cell signaling and previous research industry experience in drug development is a plus. This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers. The primary responsibility of this position will be related to the field of fibrosis, notably in the discovery of novel signaling pathways.

Responsibilities:

  • Plan and execute experiments related to the evaluation of novel targets and signaling pathways.
  • Make detailed observations, record and analyze data.
  • Troubleshoot experiments.
  • Advance drug discovery programs by interacting with other biologists, chemists and external collaborators.
  • Contribute effectively to patent, report and scientific publication writing.
  • May have the opportunity to manage one or more Research Associates.

Job Requirements:

  • PhD. in Biochemistry, Molecular Biology, Structural Biology, or related field.
  • A minimum of 5 years of experience working in antibody engineering, preferably in the pharmaceutical or biotechnology industry.
  • Experienced in antibody humanization and maturation.
  • In-depth knowledge of state-of-the-art technologies and methods for design and optimization of antibody and antibody-based therapeutics.
  • Hands-on experiences with phage-display, yeast-display, and/or antibody engineering are required
  • Strong molecular biology skills
  • High level of creativity and productivity with strong problem solving skills.
  • Ability to champion the biology efforts into new directions to achieve project milestones.
  • Strong evidence of conceptual thinking, active follow through and vigorous scientific curiosity.
  • Proven ability to work well with others in a dynamic and highly collaborative environment.
  • Exceptional interpersonal, verbal and written communication skills