Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by fibrotic disease. The Company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company’s lead product candidate, PLN-74809, is an oral, small molecule selective inhibitor of the αvβ1 and αvβ6 integrins that play a key role in multiple fibrotic pathways. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration in both idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC), and are currently in Phase 2a clinical trials for these indications. Pliant’s second product candidate, PLN-1474, is an oral, small molecule selective inhibitor of the αvβ1 integrin, in development as a potential treatment forlate-stage liver fibrosis under a partnership with Novartis. The Company also has discovery and development programs in oncology and muscular dystrophies. The Company is seeking passionate, creative, and dedicated individuals to join our team and contribute to our mission.
We are currently seeking an experienced antibody production engineer to join our Chemistry, Manufacturing, and Controls (CMC) team at Pliant to play a key role in externalized cell-line development, scale-up, and both non-clinical and clinical manufacture of Pliant’s monoclonal antibody drug candidates. The individual selected for this role will have a high-impact opportunity to establish this new modality into the CMC organization at Pliant. The ideal candidate possesses a strong understanding of cell-line development (CLD), mammalian cell protein expression and protein purification, and formulation with the ability to apply this knowledge in oversight of CLD and antibody production at one or more contract manufacturing and development organizations. The successful candidate will report directly to the Vice President, CMC and will work closely with Pliant’s Biology, Analytical Development, and Drug Product groups to address manufacturability, formulation, and stability issues and optimize the manufacturing process for producing antibodies for both non-clinical and clinical studies and commercialization. The ideal candidate is highly creative, energetic, team focused and thrives in an intellectually rewarding collaborative and science driven environment.
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