Eve-Irene Lepist, Ph.D., brings to Pliant over fifteen years of pharmaceutical industry experience in drug metabolism and pharmacokinetics in support of discovery research, translational research, and product development. Previously, Dr. Lepist held positions of increasing responsibility at the Department of Drug Metabolism, Gilead Sciences, where she led a team supporting discovery and development programs in areas of drug absorption and transporter interactions. Dr. Lepist started her career as a DMPK scientist at CV Therapeutics, where she established and worked with in vitro and in vivo models of brain penetration. Dr. Lepist has published over twenty peer-reviewed articles in areas of pharmacokinetics and pharmacodynamics, pro-drugs, and drug-transporter interactions related to absorption, distribution, and elimination with a focus on renal drug-drug interactions.
Dr. Lepist conducted her graduate research at Uppsala University, Sweden and at The Royal School of Pharmacy, Copenhagen, Denmark. She holds a Ph.D. in pharmaceutical sciences from University of Tartu, Estonia, and completed her postdoctoral research at State University of New York at Buffalo, NY.