Changing the lives of patients

We are a team that is fearless in our quest to discover, develop and commercialize breakthrough treatments for fibrotic diseases by building a leading company with dedicated, hard-working employees. Together, our mission is to transform the lives of patients.

We invite you to browse our current career opportunities and job descriptions below. If you would like to be considered for a position at Pliant Therapeutics, please submit your CV with the title of the position in the subject line to careers@pliantrx.com.

Note to Staffing and Placement Firms: 

If you are interested in submitting potential candidates for our open positions, we ask that you refrain from contacting Pliant employees directly, but rather request that you email your firm’s  information to careers@pliantrx.com. We will be happy to review your information and will contact you if a need arises to utilize your services.

Please note that all of our open positions are managed through our Human Resources department, and unsolicited resumes in advance of an agreement in place will not be accepted. Resumes sent directly to Pliant employees or our consultants will also not be accepted as referrals. Thanks in advance. We look forward to a potential collaboration as we continue to grow the Pliant team.

Current Opportunities

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking a Senior Director of Clinical Operations to provide strategic direction and leadership for the execution of clinical trials. The successful candidate will also be responsible for the day to day management of clinical operations. This role will ensure the delivery of appropriately skilled resources so that trials are delivered according to corporate objectives. The Senior Director will provide strategic direction and leadership for the execution of trials and ensure successful delivery of clinical study milestones. This role will also oversee vendor activities with appropriate risk mitigations and contingency planning.

Primary Responsibilities:

  • Primary operational leader of the clinical program implementation
  • Participate in resource allocation, prioritization and budgeting to ensure department goals and milestones are aligned and tracking to corporate objectives. Line management responsibilities include hiring talent, performance development and mentorship
  • Ensure ongoing strong vendor interactions and collaborations, including hands-on interactions and management
  • Drive selection of vendors and vendor project organization
  • Vendor, PI and project team management, oversight & communication
  • Serve as primary contact for functional area representatives in managing protocol execution
  • Develop and manage integrated study timelines and leads study strategy meetings to review trial status/progress
  • Provide input on strategy in the development of realistic project milestones and deliverables. Apply appropriate project management tools and processes
  • Multicenter and multinational trial management, principally focused on IPF and PSC
  • Manage labeling and distribution logistics for clinical supplies
  • Lead ongoing risk assessments with accompanying mitigation plans and contingency plans. Strong abilities to problem-solve and diagnose the root causes and implement the appropriate corrective actions
  • Provide input to the development and review of study and overall clinical program budgets. Take corrective measures as necessary to keep project(s) in line within agreed timelines, quality, budget and performance metrics. Assess the impact of project scope changes to understand the implications on agreed plans and budgets.
  • Manage interdisciplinary activities to ensure clinical operations collaborates effectively to set achievable goals, milestones and timelines.  Establish strong cross-functional relationships and manage cross functional resources and study deliverables.
  • Identify and implement best practices and leverage lessons learnt and process improvements
  • Ensures trial adherence to ICH/GCP/local regulations
  • Author/review study documents (Protocol, ICF, IB, Monitoring plans, SMC/IDMC/DSMB charter, CSR, statistical analysis plan)

Requirements:

  • Master’s degree, preferably in health care, life sciences, or related discipline
  • A minimum of 10 years of Clinical operations experience within the Biotech/Pharmaceutical industry
  • A minimum of 6 years of staff management and vendor management experience
  • Thorough understanding of the processes associated with executing a clinical development program including: clinical trial design, implementation, management and reporting
  • Advanced leadership, project management, resource management, administrative and technical capabilities
  • Excellent verbal and written communication skills
  • Experience with early and late phase clinical trials
  • Experience with IPF, PSC and rare diseases are a definite plus
  • Experience in direct or matrix management of clinical operations team member
  • Knowledge of the drug development process in the bio/pharmaceutical industry with an understanding of relevant regulatory requirements
  • Experience developing trial plans including, site monitoring strategies, risk mitigation strategies, trial budgets, site selection, and clinical supplies management
  • Strong project management skills with effective written and verbal
  • communication skills
  • A team player with excellent interpersonal skills and the ability to serve as the key interface for the organization on an operational level
  • Substantial experience managing contractors and interacting effectively in the establishment, oversight and maintenance of vendor relationships
  • Knowledge of GCP and ICH required, global clinical management experience preferred
  • Proficient computer skills
  • Understanding of financial principles and budget management
  • Ability to communicate with and manage senior-level stakeholder objectives

Department: Finance & Accounting

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated people to join our team and contribute to our mission.

Position Overview

Pliant Therapeutics is seeking a Senior Manager Accounting who is responsible for the financial close process, including clinical trial accounting, and other accounting operations, in accordance with GAAP, SEC requirements and best practices. The ideal candidate will have biotechnology or pharmaceutical experience, and extensive experience working with Quickbooks, managing the equity function, accounts payable function, payroll function and managing employee expense reporting tool (Expensify, Concur or similar tool). This position reports directly to the Corporate Controller. This is a highly visible role within the organization as you will be interacting directly with upper management as well.

Responsibilities:

  • Own monthly/quarterly/annual financial close, including development of processes and procedures to ensure completeness, timeliness and accuracy in financial reporting, as well as preparing journal entries and account reconciliations as part of the close process
  • Partner with procurement, FP&A and HR to oversee accounting operations in A/P and Payroll, ensuring proper internal controls and accurate flow of information
  • Participate in project teams impacting system of record for clinical and supply chain organizations
  • Assist with the administration of executive compensation programs, including annual and long-term incentive programs.
  • Ad hoc projects and financial analyses to support key business decisions and projects
  • Assists with external audits and tax reporting function
  • Leads and participates in cross-functional teams to implement finance department/corporate initiatives.
  • Train, manage, coach and mentor staff, as needed

 

Requirements:

  • Bachelor’s degree (or higher) in Accounting or Finance with at least 7 years of progressive accounting experience including managing staff; relevant biotech pharmaceutical industry experience is highly desired
  • CPA preferred
  • Prior experience working for public accounting firm is a plus
  • Strong analytical and accounting skills with understanding of US GAAP, SEC and experience operating within SOX control environment
  • Proficiency in Excel and Word and ability to learn new systems quickly
  • Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously
  • Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines
  • Ability to work independently and as part of a team
  • Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment
  • IPO experience, a plus
  • Candidates must be authorized to work in the U.S.

Description: 
Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for meeting unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking a versatile, self-motivated person to become an integral part of the DMPK team.  This position will be the drug metabolism and pharmacokinetics (DMPK) lead on project teams developing small molecule modulators of clinically meaningful targets in fibrosis.

This role will interact and collaborate cross-functionally with scientists in other groups, including chemists, biologists, biochemists, structural biologists, and computational chemists.

Job Responsibilities:

  • Serve as DMPK subject matter expert on dynamic cross-functional teams, provide in vitro and in vivo drug disposition data, interpretation, and presentations to teams.
  • Work closely with internal and external resources to assure a high level of quality and timely delivery of DMPK support.
  • Design and perform PK and PK/PD analyses to answer translational questions and to provide guidance for project teams.
  • Supervise associate scientists as required.

Qualifications/Experience: 

  • Requires a highly motivated individual with PhD degree in life sciences with 3-7 year experience.
  • Demonstrates excellent scientific skills in the design, execution and analysis of DMPK studies as well as organized data management and planning skills
  • Good verbal and written communication skills, demonstrated ability to work effectively in cross-functional teams
  • Requires hands-on experience in pharmacokinetics, drug metabolism or transporters
  • Expertise and experience in one or more of the following areas:
  • Mechanistic PK and pharmacodynamics (PD) analysis, design, interpretation, simulation, and reporting to provide guidance for drug discovery and development projects
  • Metabolite and metabolic soft-spot identification to facilitate structure-based discovery
  • Bioanalysis with previous experience in applying automation for higher throughput

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate openings are available for Scientists/Sr. Scientists with experience in the fibrosis/inflammation area. Experience in cell signaling and previous research industry experience in drug development is a plus. This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers. The primary responsibility of this position will be related to the field of fibrosis, notably in the discovery of novel signaling pathways.

Responsibilities:

  • Plan and execute experiments related to the evaluation of novel targets and signaling pathways.
  • Make detailed observations, record and analyze data.
  • Troubleshoot experiments.
  • Advance drug discovery programs by interacting with other biologists, chemists and external collaborators.
  • Contribute effectively to patent, report and scientific publication writing.
  • May have the opportunity to manage one or more Research Associates.

Job Requirements:

  • PhD. in Biochemistry, Molecular Biology, Structural Biology, or related field.
  • A minimum of 5 years of experience working in antibody engineering, preferably in the pharmaceutical or biotechnology industry.
  • Experienced in antibody humanization and maturation.
  • In-depth knowledge of state-of-the-art technologies and methods for design and optimization of antibody and antibody-based therapeutics.
  • Hands-on experiences with phage-display, yeast-display, and/or antibody engineering are required
  • Strong molecular biology skills
  • High level of creativity and productivity with strong problem solving skills.
  • Ability to champion the biology efforts into new directions to achieve project milestones.
  • Strong evidence of conceptual thinking, active follow through and vigorous scientific curiosity.
  • Proven ability to work well with others in a dynamic and highly collaborative environment.
  • Exceptional interpersonal, verbal and written communication skills

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for meeting unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate opening available for Associate Scientist/Scientist to develop translational assays of fibrosis.  Previous research experience using primary human tissue is a plus. This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and biomarkers for fibrosis.  This is an opportunity to investigate mechanisms of fibrosis across multiple organs and diseases utilizing cutting edge tools and techniques. This position will be primarily responsible for our precision cut tissue slice assay program developing and refining methods to maintain primary human and mouse tissue and evaluate antifibrotic therapeutics.  This program requires the ability to communicate and interact with external collaborators, flexibility in work hours, and strong bench and data analysis skills.

Responsibilities:

  • Plan and execute experiments related to the evaluation of novel targets and signaling pathways.
  • Develop new assays for the evaluation of compound efficacy
  • Make detailed observations, record and analyze data.
  • Troubleshoot experiments.
  • Advance drug discovery programs by interacting with other biologists, chemists and external collaborators.
  • Contribute effectively to patent, technical report and scientific publication writing.
  • May have the opportunity to manage one or more Research Associates.

Job Requirements:

  • PhD. in Cell Biology, Biochemistry or related field with 0-2 years experience or M.S. with >5 years industry experience
  • Experience working with ex vivo tissues (human and murine) desired
  • Broad practical experience and knowledge in common cell biology laboratory procedures including cell culture, qPCR, ELISA, and fluorescence microscopy
  • High level of creativity and productivity
  • Ability to work independently with strong problem-solving skills
  • Conceptual thinking, active follow through and vigorous scientific curiosity
  • Flexible schedule including some evening and weekend work, as required
  • Ability to work well with others in a dynamic and highly collaborative environment
  • Exceptional interpersonal, verbal and written communication skill

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking a talented, self-motivated and experienced Medicinal Chemist to be an integral member of our highly motivated research team to make significant contributions to therapeutic development.

Job Description

The Associate Director/Director of Medicinal Chemistry will direct and lead the overall medicinal chemistry efforts to support therapeutic development. Concrete responsibilities include, but are not limited to, the following:

• Designing and overseeing synthesis of novel chemical entities aimed to optimize potency, specificity, pharmacokinetics and in vivo efficacy

• Building the Company’s compound pipeline and structure-activity relationships

• Leading interdisciplinary project teams and working with a team of scientists to advance compounds through discovery and select development candidates

• Establishing relationships, contracts and overseeing activities at partner CROs

Requirements

• Ph.D. in Synthetic Organic Chemistry or Medicinal Chemistry with a minimum of 8 years of medicinal chemistry experience in the pharmaceutical industry

• Hands-on experience in and a proven track record of successfully designing and synthesizing novel small molecule therapies

• Comprehensive knowledge in the current practice and literature of medicinal chemistry

• Strong appreciation of structure-based design and computational modeling, physicochemical properties, ADME and preclinical toxicology, and molecular and cellular biology

• Experience in leading and managing discovery and early development projects

• Effective oral and written communication with peers and people in other functional areas

• Experience in outsourcing and managing CRO and the ability to work independently and in a dynamic team environment are a plus

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate openings are available for Sr. Research Associates in Chemistry.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers.  The primary responsibility of this position will be the synthesis, purification, and characterization of novel biologically active molecules. The successful candidate will work under the direct supervision of a Scientist or Sr Scientist.

Responsibilities:

  • Conduct multistep syntheses of complex small molecules supported with detailed characterization of intermediates and final products.
  • Contribute to exploratory research and collaborate closely with colleagues in other groups.
  • Summarize/interpret results and present findings in research meetings.
  • Execute experiments and tasks following appropriate laboratory/technical procedures.
  • Evaluate and clearly report experimental results to supervisor and colleagues on a routine basis with special attention to data quality and reproducibility.
  • Learn new laboratory techniques, troubleshoot experiments, and ensure experiments are performed to a high standard.
  • Utilize scientific literature and databases such as SciFinder to design and implement efficient synthetic routes.
  • Propose new compounds for synthesis based on synthetic knowledge and SAR.
  • Contribute to the design of experiments and new targets.

Job Requirements:

  • BS/MS in Chemistry with 3-8 years of relevant experience in synthetic organic/medicinal chemistry with potential to learn and adapt in a fast moving environment.
  • Demonstrated experience in organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, MS, HPLC, etc.).
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
  • Ability to work independently and perform well in a team environment
  • Understanding of medicinal chemistry concepts.

Pliant Therapeutics provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, Pliant Therapeutics complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.