Changing the lives of patients

We are a team that is fearless in our quest to discover, develop and commercialize breakthrough treatments for fibrotic diseases by building a leading company with dedicated, hard-working employees. Together, our mission is to transform the lives of patients.

We invite you to browse our current career opportunities and job descriptions below. If you would like to be considered for a position at Pliant Therapeutics, please submit your CV with the title of the position in the subject line to careers@pliantrx.com.

Note to Staffing and Placement Firms: 

If you are interested in submitting potential candidates for our open positions, we ask that you refrain from contacting Pliant employees directly, but rather request that you email your firm’s  information to careers@pliantrx.com. We will be happy to review your information and will contact you if a need arises to utilize your services.

Please note that all of our open positions are managed through our Human Resources department, and unsolicited resumes in advance of an agreement in place will not be accepted. Resumes sent directly to Pliant employees or our consultants will also not be accepted as referrals. Thanks in advance. We look forward to a potential collaboration as we continue to grow the Pliant team.

Current Opportunities

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate opening available for Biologist/High Throughput Screening Senior Research Associate Scientist.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers.  The successful candidate will work under the direct supervision of a Senior Scientist or Scientist.

Responsibilities

  • Lead the internal development of a high-throughput process from optimization and validation through a successful Operations workflow.
  • Design, develop, and implement in vitro assays for a variety of disease targets related to fibrosis. The candidate will validate and miniaturize the assays to identify new leads through primary screens, but also characterize potential candidates from our Medicinal Chemistry department.
  • Responsible for HTS evaluation, requiring excellent quality metrics.

Requirements

  • BS, MS in Cellular Biology, High Throughput Screening, or related field with a minimum of five years working with cellular assay development, high throughput screening.
  • Experience involving the design, optimization and validation of automated high throughput screening assays. Ability to independently execute studies and provide reports to major stakeholders (biologists and chemists). Strong understanding of data analysis packages for HTS, statistics and QC principles.
  • Strong background in assay development, solid phase binding assays and expertise in cell biology/culture and is expected to provide valuable insights to drug discovery.
  • Attention to detail and rigorous observation of variances in methods and controls.
  • Effective communication skills, ability to present data at project team meetings is essential.
  • Experience mentoring and training others.

Preferred Qualifications

  • Experience with integrin biology, protein-protein interactions, ion channel pharmacology.
  • Development of classical solid phase and cell based systems but also complex biological models including co-cultures assays.
  • Well versed into HTS technology, cellular screening approaches, FACS, imaging.
  • A strong desire to work in a fast-paced work environment with the goal of transforming the lives of people with debilitating diseases.

 

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate opening available for Biologist/High Throughput Screening Research Associate Scientist.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers. The successful candidate will work under the direct supervision of a Senior Scientist or Scientist.

Responsibilities

  • Develop a high-throughput process from optimization and validation through a successful Operations workflow.
  • Perform weekly HTS evaluation, requiring excellent quality metrics and reproducibility.
  • Develop and implement in vitro assays for a variety of disease targets related to fibrosis. The candidate will validate and miniaturize the assays to identify new leads through primary screens, but also characterize potential candidates from our Medicinal Chemistry department.
  • Provide valuable insights to drug discovery.

Job Requirements

  • BS, MS in Cellular Biology, High Throughput Screening, or related field with previous experience in cellular assay development and high throughput screening.
  • Strong background in assay development, solid phase binding assays and expertise in cell biology/culture.
  • Experience in optimization and validation of automated high throughput screening assays. Ability to execute studies and provide reports to major stakeholders (biologists and chemists). Strong understanding of data analysis packages for HTS, statistics and QC principles.
  • Attention to detail and rigorous observation of variances in methods and controls.
  • Effective communication skills.

Preferred Qualifications

  • Experience with integrin biology, protein-protein interactions, ion channel pharmacology.
  • Development of classical solid phase and cell based systems but also complex biological models including co-cultures assays.
  • Well versed in HTS technology, cellular screening approaches, FACS, imaging.
  • A strong desire to work in a fast-paced work environment with the goal of transforming the lives of people with debilitating diseases.

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate openings are available for Sr. Research Associates in Chemistry.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers.  The primary responsibility of this position will be the synthesis, purification, and characterization of novel biologically active molecules. The successful candidate will work under the direct supervision of a Scientist or Sr Scientist.

Responsibilities:

  • Conduct multistep syntheses of complex small molecules supported with detailed characterization of intermediates and final products.
  • Contribute to exploratory research and collaborate closely with colleagues in other groups.
  • Summarize/interpret results and present findings in research meetings.
  • Execute experiments and tasks following appropriate laboratory/technical procedures.
  • Evaluate and clearly report experimental results to supervisor and colleagues on a routine basis with special attention to data quality and reproducibility.
  • Learn new laboratory techniques, troubleshoot experiments, and ensure experiments are performed to a high standard.
  • Utilize scientific literature and databases such as SciFinder to design and implement efficient synthetic routes.
  • Propose new compounds for synthesis based on synthetic knowledge and SAR.
  • Contribute to the design of experiments and new targets.

Job Requirements:

  • BS/MS in Chemistry with 3-8 years of relevant experience in synthetic organic/medicinal chemistry with potential to learn and adapt in a fast moving environment.
  • Demonstrated experience in organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, MS, HPLC, etc.).
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
  • Ability to work independently and perform well in a team environment
  • Understanding of medicinal chemistry concepts.

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate openings are available for Scientists/Sr. Scientists with experience in the fibrosis/inflammation area. Experience in cell signaling and previous research industry experience in drug development is a plus. This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers. The primary responsibility of this position will be related to the field of fibrosis, notably in the discovery of novel signaling pathways.

Responsibilities:

  • Plan and execute experiments related to the evaluation of novel targets and signaling pathways.
  • Make detailed observations, record and analyze data.
  • Troubleshoot experiments.
  • Advance drug discovery programs by interacting with other biologists, chemists and external collaborators.
  • Contribute effectively to patent, report and scientific publication writing.
  • May have the opportunity to manage one or more Research Associates.

Job Requirements:

  • PhD. in Biology/Molecular Biology or equivalent.
  • Minimum of 5-8 years relevant experience in the biotechnology industry strongly preferred.
  • Broad practical experience and knowledge of integrin signaling, pathways leading to cell (epithelial, fibroblast, myofibroblast) activation in fibrotic processes and/or oncology.
  • High level of creativity and productivity with strong problem solving skills.
  • Excellent scientific expertise in fibrosis and/or inflammation conversant with the current literature.
  • Ability to champion the biology efforts into new directions to achieve project milestones.
  • Strong evidence of conceptual thinking, active follow through and vigorous scientific curiosity.
  • Proven ability to work well with others in a dynamic and highly collaborative environment.
  • Exceptional interpersonal, verbal and written communication skills

 

Description:

 

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry team in the pursuit of novel small molecules to treat fibrotic disease. The successful candidate will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy.

Responsibilities:

  • Plan and execute the synthesis, purification, and characterization of complex small molecules.
  • Integrate and utilize modern medicinal chemistry principles and tools, including structure based drug design.
  • Advance drug discovery programs by interacting with other chemists, biologists and external collaborators to understand and optimize DMPK and in vitro and in vivo pharmacological properties.
  • Contribute effectively to patent, report and scientific publication writing.
  • Execute inventive contributions towards new chemical target structures, and employ sound judgment in the evaluation and strategic decision making around early screening or literature hits.
  • May have the opportunity to manage one or more Research Associates.

Desired Skills and Experience:

  • PhD. in synthetic organic chemistry or equivalent.
  • Structure-based drug design experience preferred.
  • At least 3-10 years industry experience strongly preferred.
  • High level of creativity and productivity with strong synthetic problem solving skills.
  • Excellent scientific expertise in organic synthesis, conversant with the current literature.
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.
  • Strong evidence of conceptual thinking, active follow through and vigorous scientific curiosity.
  • Proven ability to work well with others in a dynamic and highly collaborative environment.
  • Exceptional interpersonal, verbal and written communication skills

 

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking a highly motivated and energetic AD/Director of DMPK to build our DMPK department. The successful candidate will collaborate on multidisciplinary teams and apply their experience in application of modern in vitro and in vivo DMPK assays to the optimization of small molecule drug candidates. With the ultimate goal of recommending small molecules for advancement to the clinic, in collaboration with chemistry and biology colleagues, the incumbent will integrate of chemical and bioassay data with DMPK to guide compound design. The AD/Director will supervise the work of research associates and/or CROs.   Individuals will be expected to participate in the writing and execution of patent applications, reports for regulatory submission, preparation and presentation of results at cross-functional meetings and interface productively and successfully with internal cross-functional teams/departments and external collaborators and CROs.

Responsibilities:

  • Develop and implement DMPK platform to support drug discovery programs using internal and contracted external resources
  • Design and implement strategy across the department (project, people, space, equipment, systems and work processes) for the support for all Discovery projects.
  • Lead group in in vitroand in vivo DMPK property characterization toward the optimization of research compounds from hit profiling through candidate selection.
  • Provide expertise and guidance for experimental design.
  • Provide assistance with in-depth quality review and interpretation of results.
  • Establish and manage in vitro-in vivo correlations and use these correlations in collaboration with Pharmacology to project pre-clinical and clinical doses
  • Recruit, train and develop all analytical, purification, DMPK/Bioanalytical scientists and associates.
  • Contribute to setting direction for the project teams overall and with respect to specific disciplines in DMPK.
  • Write, edit, and review technical reports and other documents in support of regulatory filings.
  • Effective management and interactions with external contractors and collaborators.
  • Adhere to the department budget, including laboratory supplies, external research grants, capital expenditures, contract research personnel and projects, and external project spending.
  • Interact productively with Scientific Advisory Board members and founders to further the company’s objectives

Desired Skills and Experience:

  • PhD. in Analytical Chemistry, Drug Metabolism, or related discipline with a minimum of 5 years of drug discovery industry experience in DMPK.
  • Demonstrated success as a DMPK lead for one or more small molecule discovery programs in the pharmaceutical or biotech industry.
  • Demonstrated record of excellence, 2+ years in leadership and management of DMPK function in industry.
  • Established ability to drive optimization of small molecule structures for desired in vivo properties through integration of complex chemical and biological data sets.
  • Expert knowledge and hands on experience with state of the art DMPK (i.e., preclinical pharmacokinetics, PK/PD relationships, metabolism, bioanalysis, and in vitro and in vivo techniques applying to these concepts)
  • Experience in delivering effective support to Medicinal Chemistry.
  • Demonstrated ability to inspire and lead scientists and associates.
  • Experience with preparation of reports for regulatory filings.
  • Proven ability to manage external contractors to meet/exceed Company goals.
  • Excellent computer skills including Microsoft Office
  • Exceptional interpersonal, verbal and written communication skills
  • Demonstrated ability as a strong decision-maker
  • Proven ability to work well with others in a dynamic and highly collaborative environment

 

Pliant Therapeutics provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, Pliant Therapeutics complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.