Changing the lives of patients

We are a team that is fearless in our quest to discover, develop and commercialize breakthrough treatments for fibrotic diseases by building a leading company with dedicated, hard-working employees. Together, our mission is to transform the lives of patients.

We invite you to browse our current career opportunities and job descriptions below. If you would like to be considered for a position at Pliant Therapeutics, please submit your CV with the title of the position in the subject line to careers@pliantrx.com.

Note to Staffing and Placement Firms: 

If you are interested in submitting potential candidates for our open positions, we ask that you refrain from contacting Pliant employees directly, but rather request that you email your firm’s  information to careers@pliantrx.com. We will be happy to review your information and will contact you if a need arises to utilize your services.

Please note that all of our open positions are managed through our Human Resources department, and unsolicited resumes in advance of an agreement in place will not be accepted. Resumes sent directly to Pliant employees or our consultants will also not be accepted as referrals. Thanks in advance. We look forward to a potential collaboration as we continue to grow the Pliant team.

Current Opportunities

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking a talented, self-motivated and experienced Medicinal Chemist to be an integral member of our highly motivated research team to make significant contributions to therapeutic development.

Job Description

The Associate Director/Director of Medicinal Chemistry will direct and lead the overall medicinal chemistry efforts to support therapeutic development. Concrete responsibilities include, but are not limited to, the following:

• Designing and overseeing synthesis of novel chemical entities aimed to optimize potency, specificity, pharmacokinetics and in vivo efficacy

• Building the Company’s compound pipeline and structure-activity relationships

• Leading interdisciplinary project teams and working with a team of scientists to advance compounds through discovery and select development candidates

• Establishing relationships, contracts and overseeing activities at partner CROs

Requirements

• Ph.D. in Synthetic Organic Chemistry or Medicinal Chemistry with a minimum of 8 years of medicinal chemistry experience in the pharmaceutical industry

• Hands-on experience in and a proven track record of successfully designing and synthesizing novel small molecule therapies

• Comprehensive knowledge in the current practice and literature of medicinal chemistry

• Strong appreciation of structure-based design and computational modeling, physicochemical properties, ADME and preclinical toxicology, and molecular and cellular biology

• Experience in leading and managing discovery and early development projects

• Effective oral and written communication with peers and people in other functional areas

• Experience in outsourcing and managing CRO and the ability to work independently and in a dynamic team environment are a plus

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Immediate openings are available for Sr. Research Associates in Chemistry.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers.  The primary responsibility of this position will be the synthesis, purification, and characterization of novel biologically active molecules. The successful candidate will work under the direct supervision of a Scientist or Sr Scientist.

Responsibilities:

  • Conduct multistep syntheses of complex small molecules supported with detailed characterization of intermediates and final products.
  • Contribute to exploratory research and collaborate closely with colleagues in other groups.
  • Summarize/interpret results and present findings in research meetings.
  • Execute experiments and tasks following appropriate laboratory/technical procedures.
  • Evaluate and clearly report experimental results to supervisor and colleagues on a routine basis with special attention to data quality and reproducibility.
  • Learn new laboratory techniques, troubleshoot experiments, and ensure experiments are performed to a high standard.
  • Utilize scientific literature and databases such as SciFinder to design and implement efficient synthetic routes.
  • Propose new compounds for synthesis based on synthetic knowledge and SAR.
  • Contribute to the design of experiments and new targets.

Job Requirements:

  • BS/MS in Chemistry with 3-8 years of relevant experience in synthetic organic/medicinal chemistry with potential to learn and adapt in a fast moving environment.
  • Demonstrated experience in organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, MS, HPLC, etc.).
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
  • Ability to work independently and perform well in a team environment
  • Understanding of medicinal chemistry concepts.

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company is seeking passionate, creative and dedicated individuals to join our team and contribute to our mission.

Position Overview

Pliant is seeking a highly motivated and energetic Research Associate / Senior Research Associate to join our DMPK department. The successful candidate will be responsible for performing in vitro drug metabolism studies and in vivo PK sample analysis to inform compound design and help advance compounds to the clinic. He or she will participate on multidisciplinary teams, working closely with chemistry and biology colleagues to contribute to Pliant’s overall drug discovery and development efforts.

Job responsibilities include but not limited to:

· Perform bioanalytical analysis on preclinical PK samples

· Establish and perform in vitro ADME assays, such as permeability (MDCK or Caco2), metabolic stability (microsome, plasma, and hepatocyte), plasma protein binding, CYP inhibition, reaction phenotyping, and metabolite identification, etc.

· Participate in department meetings and present data

· Assist with writing and reviewing technical reports and other documents in support of regulatory filings

· Work collaboratively with internal colleagues, external contractors and collaborators

· Adhere to the department budget

· Keep abreast of scientific literature

Desired Skills and Experience:

· BS/MS degree in Chemistry, Biology, Drug Metabolism, Biopharmaceutical Sciences, or related discipline

· 5+ years of relevant industry experience in DMPK, with potential to learn and adapt in a fast moving environment.

· Hands-on experience with state-of-the-art bioanalytical equipment and methodology (e.g. Sciex ABI 4000/6500 mass spectrometer, Analyst software, Shimadzu HPLC system) is a must. So is the ability to troubleshoot instrumentation related issues independently.

· The candidate should be self-motivated, fast learner, proactive in problem solving, and able to manage timelines and priorities.

· The candidate should be organized, detail-oriented, with excellent record-keeping skills.

· The candidate should be able to work both independently and as part of a team, and have a desire to learn new methods and to work on new assignments.

· The candidate should have good interpersonal skills, and effective written and oral communication skills.

· Proven ability to work well with others in a dynamic and highly collaborative environment

· Excellent computer skills

Description:

Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians.  The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules.  The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry team in the pursuit of novel small molecules to treat fibrotic disease. The successful candidate will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy.

 Responsibilities:

  • Plan and execute the synthesis, purification, and characterization of complex small molecules.
  • Integrate and utilize modern medicinal chemistry principles and tools, including structure based drug design.
  • Advance drug discovery programs by interacting with other chemists, biologists and external collaborators to understand and optimize DMPK and in vitro and in vivo pharmacological properties.
  • Contribute effectively to patent, report and scientific publication writing.
  • Execute inventive contributions towards new chemical target structures, and employ sound judgment in the evaluation and strategic decision making around early screening or literature hits.
  • May have the opportunity to manage one or more Research Associates.

Desired Skills and Experience:

  • PhD. in synthetic organic chemistry or equivalent.
  • Structure-based drug design experience preferred.
  • At least 2-6 years industry experience strongly preferred.
  • High level of creativity and productivity with strong synthetic problem solving skills.
  • Excellent scientific expertise in organic synthesis, conversant with the current literature.
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.
  • Strong evidence of conceptual thinking, active follow through and vigorous scientific curiosity.
  • Proven ability to work well with others in a dynamic and highly collaborative environment.
  • Exceptional interpersonal, verbal and written communication skills

 

Pliant Therapeutics provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, Pliant Therapeutics complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.