Bexotegrast (PLN-74809): IPF Bexotegrast (PLN-74809): IPF

Bexotegrast (PLN-74809): IPF

Bexotegrast as a Potential Treatment for Idiopathic Pulmonary Fibrosis (IPF)

Our lead product candidate, bexotegrast (PLN-74809), is an oral, small molecule, dual-selective inhibitor of the αvβ6 and αvβ1 integrins. It is being developed for the treatment of idiopathic pulmonary fibrosis (IPF).

The αvβ6 and αvβ1 integrins are expressed at very low levels in normal tissues but are upregulated in the pulmonary tissues of IPF patients. Both integrins serve as activators of TGF-ß, leading to increased collagen production and, ultimately, fibrosis in these tissues. By blocking the activation of TGF-ß by both αvβ6 and αvβ1, we believe bexotegrast may slow and potentially halt the progression of fibrosis in this patient population.

A part of IPF and PSC scheme

Bexotegrast (PLN-74809) – Pliant’s Tissue-Specific Approach to Treating Fibrosis

The Role of Integrins in Fibrosis

BEACON-IPF logo

BEACON-IPF is a 52-week, multinational, randomized, dose-ranging, double-blind, placebo-controlled Phase 2b trial evaluating bexotegrast at doses of 160 mg or 320 mg in patients with IPF.

STATUS: Enrolling

To learn more, please visit BeaconIPF.com or ClinicalTrials.gov using the identifier NCT06097260.

Program Highlights

  • INTEGRIS-IPF, a global Phase 2a trial in IPF, data reported
  • Currently only two existing FDA-approved therapies for IPF, both shown modest slowing of disease progression
  • Medical need remains high

Development Status

  • BEACON-IPF, a global Phase 2b trial in IPF, enrolling
  • Granted Orphan Drug Designation from FDA and EMA
  • Granted Fast Track Designation from FDA