Our team has unmatched expertise in fibrosis biology and is focused on discovering and developing novel targeted therapies to address life-threatening fibrotic diseases. Our research in a variety of forums is regularly published and presented at medical and scientific conferences.
Advancing Discoveries in Fibrosis
Papers
- Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF →
- TGF-β as a driver of fibrosis: physiological roles and therapeutic opportunities →
- Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness →
- Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations →
- The integrin αvβ6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis →
- The αvβ1 integrin plays a critical in vivo role in tissue fibrosis →
- Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs →
- Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts →
- Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis →
- Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies →
Posters & Presentations
Posters & Presentations
- Dual inhibition of integrins αvβ6 and αvβ1 decreases portal pressure and liver fibrosis in rate with biliary cirrhosis →
- Rationale for evaluation of PLN-74809 treatment in participants with primary sclerosing cholangitis in a phase 2a study INTEGRIS-PSC →
- Increased Laminin Binding Through Integrin Activation Protects Dystrophic Muscle (Oral Presentation - New Directions Conference 2022) →
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- Profiling fibrosis regression in a rat model of non-alcoholic steatohepatitis →
- PK/PD assessment of an oral, selective αvβ6 /αvβ1 integrin dual antagonist, PLN-74809, for the treatment of idiopathic pulmonary fibrosis →
- Dual αvβ6 /αvβ1 inhibitor PLN-74809 blocks multiple TGF-β activation pathways associated with IPF →
- PLN-74809, a dual αvβ6/αvβ1 integrin inhibitor, inhibits fibrosis in precision-cut liver tissue from PSC and PBC patients and the Mdr2 knockout mouse →
- PLN-74809, a dual αvβ6/αvβ1, oral, selective integrin inhibitor, is well tolerated and reduces lung TGF-β activity in healthy volunteers →