The INTEGRIS-IPF clinical trial is studying PLN-74809, an oral investigational medicine designed to directly target the development of lung fibrosis (when tissue becomes damaged and scarred, affecting normal function of the organ). The medicine has been tested in over 180 individuals already and was well tolerated. It is taken once per day for 12 weeks.
By stopping the cellular process that causes fibrosis, PLN-74809 may have the potential to slow or stop the progressive decline in lung function that happens with IPF. This study will help determine if PLN-74809 affects worsening of the disease and improves quality of life.
What to expect in the INTEGRIS-IPF clinical trial
The study will consist of:
- A screening period, up to 28 days
- A treatment period of 12 weeks
- A follow-up period of one week
During the study period, you will have a total of seven visits to assess safety and lung function, including detailed lung imaging. Some of these visits will be on site with your doctors. At-home option: If you and your doctor agree, a study nurse may come to your home to conduct a portion of the required appointments. You will continue to receive standard of care treatment during the duration of your participation in the clinical trial.
Can I participate?
Talk to your doctor about participating in this clinical trial if:
- You are a patient with confirmed diagnosis of idiopathic pulmonary fibrosis, or IPF
- You are over the age of 40
If you are currently taking an IPF medication, like nintedanib or pirfenidone, you may enroll in this study and continue to take this medication.
- The trial is open to women and men
- The trial will include 60 study sites across the U.S. and the rest of the world
We are committed to protecting patients and clinicians from the spread of COVID-19. Our clinical trial sites are following all government and institutional safety guidelines.
Additionally, we are minimizing participants’ visits to trial sites by offering home-health solutions – with some tests and measures conducted through telehealth appointments in participant homes.
Pliant Therapeutics will continue to work closely with site investigators and update our practices accordingly to ensure the safe continuation of the trial.