Research Associate, Analytical Chemistry

An immediate opening is available for an Analytical Research Associate Chemist in Chemistry.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates.

The RA Analytical Chemist is responsible for daily analysis and processing of complex materials used to support multiple Pliant drug discovery programs. Position is full time and provides opportunity to use teamwork, innovation skills and advanced laboratory equipment to solve challenging chemical problems. The job will involve sample processing and method development using analytical HPLC, preparative HPLC, normal phase purification and LCMS, and will work closely with our medicinal chemistry, compound management and in vitro biology teams.


  • Sample preparation and analysis by HPLC and LC-MS
  • Purification of medicinal chemistry samples from milligram to gram scale in single and parallel formats
  • Quality control of purified compounds, and subsequent processing for registration, storage and biological screening
  • Maintain and operate analytical and preparative chromatographic instrumentation
  • Maintain high level of scientific standards and safety practices
  • Keep current and accurate records of project research and related activities according to Pliant policies
  • Stay current with technology advances and be proactive in incorporating new ideas to improve drug discovery process
  • Collaborate effectively with diverse scientific discovery teams


  • BS/MS in Organic Chemistry, Analytical Chemistry or closely related field with typically 0+ years (MS); or 2+ years (BS) of job-related experience
  • Hands-on experience with analytical HPLC, preparative HPLC, and mass spectrometry
  • Ability to operate and troubleshoot a variety of hardware/software platforms
  • Proven effective organizational, written and verbal communication skills and ability to interact with scientists and engineers
  • Awareness of synthetic organic chemistry and the ability to communicate effectively with medicinal chemistry and biology teams
  • Experience with instrument troubleshooting and maintenance preferred
  • Experience with laboratory automation preferred