Senior Research Associate, DMPK

Pliant Therapeutics is seeking an enthusiastic Senior Research Associate to join our department of Drug Metabolism and Pharmacokinetics (DMPK). In this rewarding, dynamic environment the successful candidate will be responsible for conducting in vitro assays including plasma protein binding, hepatocyte stability, CYP inhibition and related experiments to characterize the ADME properties of novel chemical entities. In addition, significant opportunity exists to directly support discovery project teams and represent DMPK in a highly impactful and visible role.


  • Design and conduct in vitro ADME assays to support discovery/development project teams
  • Collect, analyze, summarize, and upload to internal databases and report high quality data in a timely manner
  • Effectively communicate and collaborate with multiple team members across disciplines
  • Participate in project and DMPK meetings


  • Hands-on laboratory experience with in vitro DMPK assays (plasma protein binding, metabolic stability, hepatocyte incubations, and related assays)
  • Experience with small molecule LC-MS/MS bioanalysis; sample processing and preparation
  • Solid understanding of key ADME/PK concepts and principles
  • Ability to troubleshoot in vitro assays and small molecule bioanalysis
  • Excellent interpersonal skills and team spirit
  • DMPK representation in project team environment
  • Bachelor’s degree (B.S./B.A.) or equivalent in a scientifically related discipline