Pliant’s lead program, PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts. PLN-74809 has entered clinical testing, following FDA- approval of the IND.
Pliant’s second program is a small molecule, selective inhibitor of αVβ1 for the treatment of end-stage liver fibrosis in NASH. Clinical testing is anticipated to start in 2019.